Additional file 1 of Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk

Additional file 1: Supplementary Methods. Wearable device-based Physical Activity and Sleep Classification. Supplementary Figure 1: Flow diagram of participants in the study. Supplementary Figure 2: Dose-response associations of each individual exposure (sleep duration, daily MVPA duration, and diet quality score) with all-cause mortality risk (n = 59,078; events = 2,458). Supplementary Figure 3: Dose-response associations of each individual exposure (sleep duration, daily MVPA duration, and diet quality score) with all-cause mortality risk using a guideline oriented reference (n = 59,078; events = 2,458). Supplementary Figure 4: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with absolute all-cause mortality risk per 10,000 person-years (n = 59,078; events = 2,458). Supplementary Figure 5: Absolute all-cause mortality risk associated with concurrent variations in sleep, MVPA, and dietary quality score (n = 59,078; events = 2,458). Supplementary Figure 6: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality excluding poor health individuals (n = 51,164; events = 1,887). Supplementary Figure 7: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality excluding individuals with baseline CVD or cancer (n = 49,786; events = 1,637). Supplementary Figure 8: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality excluding individuals with potentially sparse or outlier data (n = 48,670; events = 1,888). Supplementary Figure 9: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality adjusted for device measured sedentary behaviour (n = 59,078; events = 2,458). Supplementary Figure 10: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality adjusted for BMI (n = 58,363; events = 2,405). Supplementary Figure 11: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality adjusted for sleep characteristics (n = 37,475; events = 1,506). Supplementary Figure 12: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality using the proportion of ultra-processed food (n = 41,936; events = 1,758). Supplementary Figure 13: Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality adjusted for total energy intake (n = 42,990; 1,758 events). Supplementary Table 1: Diet quality score index for food-frequency questionnaire dietary data.Supplementary Table 2: Sample size and all-cause mortality events for each Sleep, Physical Activity, and Nutrition category. Supplementary Table 3: Covariate definitions. Supplementary Table 4: Model variance inflation factors for combined SPAN behaviours. Supplementary Table 5: Model variance inflation factors for individual SPAN behaviours. Supplementary Table 6: NOVA classification of food groups for 24-hour dietary recall data. Supplementary Table 7: STROBE statement. Supplementary Table 8: Relative excess risk due to interaction.