Talarombrevisone A, an <i>β</i>-aminopropionate with two polyketide units, isolated from an endophytic fungus <i>Talaromyces brevis</i>

Talarombrevisone A (<b>1</b>), Which is a <i>β</i>-aminopropionate compound containing two polyketide units, and two known compounds Ethyl linoleate (<b>2</b>) and Talaromycin A (<b>3</b>) were isolated from <i>Talaromyces brevis</i>, an endophytic fungus of <i>Cupressus chengiana</i>. Structure of <b>1</b> was elucidated by infra-red, mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance (NMR) spectra. The inhibitory activity on phosphodiesterase 1 of the three compounds was investigated. Among them, <b>3</b> showed moderate activity with inhibitory rate of 58.35% at 271.6 μM.