Three bioactive dibenzocyclooctadiene lignans from the fruits of <i>Kadsura coccinea</i>

Three new dibenzocyclooctadiene lignans, namely, kadcolignan H-J (<b>1</b>–<b>3</b>), were isolated from the ethanol extract of <i>Kadsura coccinea</i> fruits. Their molecular structures, including absolute configurations, were elucidated through comprehensive spectroscopic analyses. The hepatoprotective effects of kadcolignan H-J (<b>1</b>–<b>3)</b> were subsequently evaluated. Both kadcolignan H (<b>1)</b> and kadcolignan J <b>(3)</b> demonstrated inhibitory effects on triglyceride and total cholesterol levels, whereas all isolated compounds effectively reduced the levels of free fatty acids-induced reactive oxygen species in HepG2 cells.