CostaTJ_ERaOE_Supplementary (AJP-Heart & Circ)
We have revealed for the first time that overexpression of adipose tissue estrogen receptor α (ERα<sup>OE</sup>) amplifies the anti-contractile effect of mesenteric PVAT via the biosynthesis of NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), and this overexpression is protective against HFD-induced PVAT dysfunction. Collectively, these data demonstrate an important mechanism by which ERα signaling is vasculoprotective in the context of PVAT.
Publication Details
- Journal
- Figshare
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6084/m9.figshare.28296770.v2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00