Additional file 8 of Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum

Additional file 8: Overview of metabolic pathway alterations and ribosomal protein expression changes in Av. paragallinarum following GR knockout. The diagram depicts a comprehensive map of metabolic processes with enzymes coded by differentially expressed genes (DEGs) following the GR gene disruption. Blue boxes represent enzymes associated with metabolic pathways that were not detected; green boxes indicate enzymes that were detected but did not show significant expression changes; red boxes signify downregulated enzymes, and purple boxes signify upregulated enzymes. In addition, upregulation in ribosomal proteins is denoted by pink shading in the ribosomal structure to the right. The metabolic pathways and corresponding enzymes are organized around the TCA cycle at the center, branching out to include amino acid metabolism, purine metabolism, and the glutathione cycle, highlighting the interconnectivity and complex response to the oxidative stress induced by the absence of GR.