Additional file 1 of Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells

Additional file 1: Supplementary figures S1-S4. Fig. S1. SsdA domain structure, function, and phylogenetic family. Fig. S2. Schematic diagrams of cytosine base editors. Fig. S3. C-to-T editing efficiencies of the intronized SsdA-CBEs and hA3A-CBE in N. benthamiana. Fig. S4. Cryo-EM structure of SsdAtox and AlphaFold2-predicted structure of SsdAG103S. Supplementary Sequences. Sequences of cytosine base editor architectures.