Additional file 5 of Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

Additional file 5. Supplementary Figure 5. AEP inhibition sensitizes cancer cells to genotoxic stress. (A) Heatmap showing the levels of protein (AEP and ATR) expressed in breast cancer patients dividing patients in four groups (AEPhigh/ATRlow; AEPlow/ATRhigh; AEPlow/ATRlow; AEPhigh/ ATRhigh). (B) Kaplan-Meier analysis in AEPlow/ATRlow (cyan dots) or AEPhigh/ATRhigh (red dots) breast cancer patients at the protein level. (C) Kaplan-Meier analysis in breast cancer patients expressing high ATR protein levels treated (red dots) or untreated (cyan dots) with radiation. (D) Kaplan-Meier analysis in breast cancer patients expressing high protein AEP levels treated (red dots) or untreated (cyan dots) with radiation. (E) Kaplan-Meier analysis in AEPlow/ATRlow breast cancer patients treated (red dots) or untreated (cyan dots) with radiation. (F) Dose response of cisplatin in U2OS cell in the presence (magenta bars) or absence of MVO (green bars). (G) Dose response of etoposide in U2OS cell in the presence (magenta bars) or absence of MVO (green bars). ns: no significant, * p < 0.05.