Additional file 1 of A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model
Additional file 1. Figure S1: Comparison of different siPOOL concentrations. Figure S2: Quantification of αSyn total intracellular and extracellular levels upon knockdown of SX5. Figure S3: Investigation of the effect of the knockdown of other SNXs. Figure S4: Brefeldin A (BFA) treatment led to Golgi fragmentation and cytotoxicity. Figure S5: The figure shows a version of panel c of panel 6 from the main manuscript with inclusion of the red channel that shows the signal of labeled αSyn. Table S1: Antibodies used for Western blot analysis. Table S2: Antibodies used for immunocytochemistry. Supplementary methods of Brefeldin A treatment.
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- German Center for Neurodegenerative Diseases (DE)
- Medizinische Hochschule Hannover (DE)
- Munich Cluster for Systems Neurology (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Figshare
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6084/m9.figshare.29219838.v1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00