Effect of PERMA-based psychological intervention and predictive care in malignant tumor patients following chemotherapy

Alleviating the toxic and adverse reactions associated with chemotherapy is crucial for improving patient outcomes. This study aimed to assess the impacts of positive emotion, engagement, relationships, meaning, and accomplishment (PERMA) model-based psychological interventions and predictive chemotherapy reaction nursing on patients with malignant tumors following chemotherapy. The control group (<i>n</i> = 43) received conventional care, while the observation group (<i>n</i> = 43) received psychological intervention based on PERMA model alongside predictive nursing care. Chemotherapy-induced toxicity and side effects, fatigue levels, coping mode, psychological status, and quality of life were assessed. Compared to the control group, the observation group exhibited a lower incidence of gastrointestinal adverse reactions, myelosuppression, alopecia, and oral ulcers (<i>p</i> &lt; 0.05), reduced behavioral, cognitive, somatic, and emotional fatigue (<i>p</i> &lt; 0.001), lower scores in avoidance and yielding coping styles (<i>p</i> &lt; 0.001), higher scores in confrontation coding mode (<i>p</i> = 0.056), improved quality of life, and better outcomes in anxiety, depression, and overall psychological state of patients (<i>p</i> &lt; 0.001). PERMA model-based psychological interventions and predictive chemotherapy reaction nursing interventions effectively reduce the incidence of chemotherapy-induced toxicity, alleviate fatigue, enhance quality of life, and improve psychological well-being in cancer patients. This study looked at ways to help people with cancer feel better during chemotherapy. By offering emotional support and thoughtful care, patients had fewer side effects, felt less tired, were in a better mood, and lived more comfortably while going through treatment.