Additional file 3 of Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis

Supplementary material 3: S3. Correlation analyses of ZFAS1 and ZNFX1 in publicly available scRNA-seq datasets. (A) Cell population distribution of all epithelial cell types (AT1, AT2, Basal, Basal-d, Basal-px, Cil-px, Cilia, Club, Goblet, Ionocyte, Mucous, Proliferating epithelial, Serous) with cigarette smoking status from eight scRNA-seq cohorts (104 samples). (B) Correlation analyses of ZFAS1 and ZNFX1 in three epithelial subtypes (AT1, AT2, and Club). All three epithelial subtypes have more negative coefficients in smokers than never-smokers, with dramatic significance. The negative coefficients come from the exclusive expression of ZFAS1 and ZNFX1 in those epithelia. (C) Summarization of all 13 epithelial cell types with cell numbers, p-values, and correlation values in total, never-smoker, and smoker groups.