Additional file 1 of HELLS is required for maintaining proper DNA modification at human satellite repeats
Additional file 1. Fig. S1: Characterization of HELLS KO and DNMT mutant DNA methylation landscapes. Fig. S2: Characterization of HELLS KO and DNMT mutant DNA methylation levels at satellite repeats. Fig. S3: HELLS is indispensable for maintenance of DNA methylation at satellite repeats. Fig. S4: Chromatin and transcriptional features of HELLS KO iPSCs. Fig. S5: Overview of delta DNA methylation between WT and HELLS KO across individual chromosomes. Fig. S6: HELLS is not required to remodel enhancer landscapes essential for early embryonic lineage formation. Fig. S7: Gating strategy for sorting three-germ layer differentiated human iPSCs.
Institutions
- University of Potsdam (DE)
- Max Planck Institute for Molecular Genetics (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Figshare
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6084/m9.figshare.29595505
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 0.00