Additional file 1 of Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks

Additional file 1: Legends for Supplementary Figures and Tables. Fig. S1: Schematics of the histone modification signatures associated with various enhancer activity states. Fig. S2: Examples of Primed, Poised, and Non-primed hNPC enhancers. Fig. S3: Relative proportions of specific and non-specific lineage enhancer states. Fig. S4: Comparisons between ePrimed and ePoised human lineage-specific enhancer subgroups. Fig. S5: hESC H3K4me1 levels correlate with hESC H2K27ac levels at ePrimed enhancers. Fig. S6: Identification of mEND enhancer subgroups. Fig. S7: Genes associated with mECT and mEND enhancers. Fig. S8: Fetal and Somatic expression of ePrimed enhancer associated genes. Fig. S9: E11.5 mForebrain enhancers overlapping VISTA annotated enhancers. Fig. S10: Additional epigenetic profiling of fetal brain enhancers and DNA methylation of ePrimed enhancers within DNMT/TET KOs and gastrulation. Fig. S11: ePrimed enhancer associated gene network analysis. Fig. S12: Identification of human late-embryonic liver and kidney ePrimed enhancers. Fig. S13: Identification of mouse E11.5 liver and heart ePrimed enhancers. Fig. S14: Conservation of mouse and human ePrimed enhancers and associated genes. Fig. S15: Dynamics of ePrimed upon a cell fate transition into an alternative lineage. Fig. S16: DNA hypomethylation of ePrimed enhancers within somatic tissues. Fig. S17: ePrimed 7pcw fetal brain enhancers within HipSci donor lines.