Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids and their neuroprotective activities of against CORT-induced apoptosis of PC12 from the <i>Schisandra chinensis</i> leaves and stems

Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids (SNTs), Wuweizinortriters A and B (1–2) were successfully isolated from the ethanol extracts of the leaves and stems of <i>Schisandra chinensis.</i>, the determination of their structures was achieved by using NMR, MS, UV, and carbon spectrum calculation. Wuweizinortriters A and B (25 μM) moderately protected PC12 cells from CORT-induced apoptosis, with the viability increasing by 18.02% and 20.33% respectively, compared to the model group.

Publication Details

Journal
Figshare
Published
2025-01-01
DOI
https://doi.org/10.6084/m9.figshare.28646380.v1
Primary Topic
Plant-derived Lignans Synthesis and Bioactivity
Type
article
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article

Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids and their neuroprotective activities of against CORT-induced apoptosis of PC12 from the Schisandra chinensis leaves and stems

Figshare
Plant-derived Lignans Synthesis and Bioactivity
article

Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids and their neuroprotective activities of against CORT-induced apoptosis of PC12 from the Schisandra chinensis leaves and stems

article en

Abstract

Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids (SNTs), Wuweizinortriters A and B (1–2) were successfully isolated from the ethanol extracts of the leaves and stems of <i>Schisandra chinensis.</i>, the determination of their structures was achieved by using NMR, MS, UV, and carbon spectrum calculation. Wuweizinortriters A and B (25 μM) moderately protected PC12 cells from CORT-induced apoptosis, with the viability increasing by 18.02% and 20.33% respectively, compared to the model group.

Figshare
Openalex Percentile: Top 61%
Plant-derived Lignans Synthesis and Bioactivity
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Two rare C14-C15 chemical bond-breaking 7/5/5 skeleton schinortriterpenoids and their neuroprotective activities of against CORT-induced apoptosis of PC12 from the <i>Schisandra chinensis</i> leaves and stems · Figshare (2025) | TGRS Research Map | TGRS