Additional file 1 of The conclusiveness of trial sequential analysis varies with estimation of between-study variance: a case study

Supplementary Material 1. Data source, effect estimates, and assessment of heterogeneity, Equations for between-study variance estimators, Equations for quantities used in trial sequential analysis, TSA software and R package smiles return the same required information size, R code to perform the sequential analysis in this study, Summary of quantities computed in the trial sequential analyses for this study, Flowchart of the steps in using the random-effect model in trial sequential analysis, Scatter plots of the adjustment factor (AF) versus the estimated between-study variance ( $$\widehat{{\varvec{\tau}}}$$ τ ^ 2), Descriptive statistics and variability of quantities in the trial sequential analyses.