<b><i>Novel Germline Pathogenic Variant in Familial Multiple Endocrine Neoplasia Type 1</i></b>

Multiple Endocrine Neoplasia type 1 (MEN1) is a rare genetic disease, characterized by co-occurrence of several lesions of the endocrine system.In MEN1, the pathogenic <i>MEN1</i> gene mutations lead to the Abnormal expression of menin, a critical tumor suppressor protein. We here reported a case of a 14‐year‐old male with insulinoma and primary hyperparathyroidism.