Chemical constituents from <i>Ficus vogeliana</i> Miq (Moraceae)

The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of <i>Ficus vogeliana</i> Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (<b>1</b>), two compounds (<b>2</b> and <b>4</b>) obtained for the first time from a natural source, as well as sixteen known compounds (<b>3, 5 </b>−<b> 19</b>). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound <b>7</b> showed moderate activity against <i>E. coli</i> with a MIC value of 31.25 µg/mL, whilst compound <b>13</b> exhibited moderate activity against <i>S. typhimurium</i> with MIC value of 31.25 µg/mL. The leaf, root, and stem bark extracts displayed significant potency against <i>E. coli</i> with MIC values of 62.5 μg/mL, 31.25 µg/mL, and 62.5 μg/mL, respectively. Finally, the chemophenetic significance of the isolated compounds is discussed.

Publication Details

Journal
Figshare
Published
2025-03-06
DOI
https://doi.org/10.6084/m9.figshare.28550606.v1
Primary Topic
Phytochemistry and biological activities of Ficus species
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article
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Chemical constituents from Ficus vogeliana Miq (Moraceae)

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Phytochemistry and biological activities of Ficus species
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Chemical constituents from Ficus vogeliana Miq (Moraceae)

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Abstract

The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of <i>Ficus vogeliana</i> Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (<b>1</b>), two compounds (<b>2</b> and <b>4</b>) obtained for the first time from a natural source, as well as sixteen known compounds (<b>3, 5 </b>−<b> 19</b>). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound <b>7</b> showed moderate activity against <i>E. coli</i> with a MIC value of 31.25 µg/mL, whilst compound <b>13</b> exhibited moderate activity against <i>S. typhimurium</i> with MIC value of 31.25 µg/mL. The leaf, root, and stem bark extracts displayed significant potency against <i>E. coli</i> with MIC values of 62.5 μg/mL, 31.25 µg/mL, and 62.5 μg/mL, respectively. Finally, the chemophenetic significance of the isolated compounds is discussed.

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Phytochemistry and biological activities of Ficus species
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