SEN-GENOME Blank Consent Form

The human reference genome (GRCh38), primarily sourced from individuals of European descent, falls short in capturing the vast genetic diversity across global populations. Efforts to diversify the reference genome, such as through pan-genome projects, face challenges in accessibility and representation, exacerbating the scarcity of African genomic data crucial for studying diseases prevalent in these populations.Addressing this gap, Sherman et al. proposed constructing reference genomes tailored to distinct human sub-populations. Their African Pan-Genome (APG) initiative highlighted the substantial genetic variation missing from the GRCh38 human reference genome, emphasizing the necessity for population-specific genomes.In response, local initiatives like the Senegalese Genome project (SEN-GENOME) has emerged, striving to document the genomes of historically overlooked populations. SEN-GENOME embodies community-driven decentralized research. With meticulous recruitment criteria and ethical practices, it aims to sequence 1000 genomes from 31 ethnolinguistic groups, in the fourteen administrative regions of Senegal (West-Africa), fostering local genomic research and precision medicine tailored to the region. Key to SEN-GENOME’s success is its commitment to local governance of genomic data, capacity building, and integration with broader pan-genome projects in Africa.Despite the complexities of data harmonization and sharing, our collaborative efforts are aligned with common goals, ensuring steady progress towards a comprehensive human pan-genome. We invite and welcome collaboration with other research entities to achieve this shared vision.In summary, local initiatives such as SEN-GENOME are pivotal in bridging genomic disparities, offering pathways to equitable and inclusive genomic research. Collaborative endeavors guided by a collective vision for human health, will propel us towards a more encompassing understanding of the human genome and a better health through genomic medicine.