Celastrol as a Potential Phytopharmaceutical for Medulloblastoma Therapy: Assessing Efficacy and Cardiotoxicity

Cancer remains a pervasive global health challenge associated with substantial mortality. While current chemotherapy treatments are efficacious, they frequently entail significant off-target effects, notably hepatotoxicity, neurotoxicity, and cardiotoxicity, impacting long-term patient survival. Childhood cancers, including medulloblastoma, present additional complexities due to the heightened susceptibility of these individuals to these off-target effects3. Thus, a compelling need exists to evaluate novel therapeutics with heightened efficacy and diminished off-target effects.This article has been reviewed by Dr Matthew Jones, Lecturer in Biomedicine (Physiology), University of Salford. The Editorial Team would like to thank him for his time and contributions.