PATHOPHYSIOLOGICAL ASPECTS OF NEPHRO- AND HEPATOTOXICITY DURING CHEMOTHERAPY AND THE ROLE OF AMINO ACID SUPPORT

Chemotherapy of malignant neoplasms remains a key component in the treatment of oncological diseases, but is accompanied by a number of side effects, the most dangerous of which are toxic liver and kidney damage. These complications often limit the possibility of a full course of therapy, and in severe cases lead to the cancellation of treatment. Particularly pronounced organ toxicity is observed with the use of platinum series drugs ( cisplatin , carboplatin ), anthracyclines ( doxorubicin ), taxanes ( paclitaxel , docetaxel ), methotrexate and ifosfamide . Understanding the pathophysiological mechanisms of toxicity, as well as the search for ways to correct them, including through nutritional amino acid support, is an important area of clinical oncology.