Synthesis, Characterization and Antimiccrobial Screening of Some Thiadiazole Derivatives

Heterocycles like thiadiazole plays a vital role owing to its wide range of therapeutic activities like antibacterial, anti-fungal, anti-inflammatory, anti-convulsant, antiviral, anticancer and antihistaminic. In the present project, an attempt was made to synthesize some of newer 1,3,4-thiadiazoe derivatives and evaluate their antimicrobial activity quantitatively and qualitatively. The Synthesized compounds were characterized by TLC, melting point and spectral data. Melting points were determined by using precision melting point apparatus in open capillaries and are uncorrected. The Purity of the compounds was checked by TLC on silica gel G plates using methanol: chloroform (1:9) solvent system iodine chambers used as a visualizing agent. The structures of these compounds are supported by IR, H-NMR and mass analysis. The antibacterial and antifungal activities of thiadiazole derivatives also reported.