A Prospective Interventional Study on Efficacy of Mifepristone in The Medical Management of Uterine Leiomyomas

Abstract Background: Medical treatment with T. Mifepristone 25mg is an effective method in reducing size, number, volume of myomas and decreasing amount of blood loss, regression of symptoms and decreasing number of surgery. Objective · To determine the efficacy of Mifepristone in the medical management of uterine leiomyomas. · To assess the need of surgical management. Methods: It is a prospective interventional study conducted at Sri Sidharatha Medical Collage, Tumkuru. The effects of Mifepristone 25mg administrations for 3 months was carried out after satisfying inclusion and exclusion criteria, relevant medical history and general physical examination and systemic examination was done. All the patients were subjected to ultrasound abdomen and pelvis to know the location, size, number, volume of myomas and endometrial thickness before the start of treatment Results: There was a statistically significant increase in Hemoglobin after treatment (P < 0.001) and significant reduction in fibroid size post-treatment (P< 0.001). Conclusion: Mifepristone 25mg showed significant reduction in size, volume and improvement in symptoms in a woman with uterine leiomyomas.