Development And Validation of RP HPLC Method for Estimation of Galantamine in Tablet Dosage Form

A simple, precise, accurate, and robust RP-HPLC method was developed and validated for the quantitative estimation of galantamine in tablet dosage form. The chromatographic separation was achieved on a [insert column type, e.g., C18 column (250 mm × 4.6 mm, 5 µm particle size)] using a mobile phase consisting of [e.g., methanol:water or acetonitrile:buffer] in the ratio [e.g., 70:30 v/v], at a flow rate of [e.g., 1.0 mL/min]. The detection was carried out at [e.g., 288 nm] using a UV detector. The method was validated as per ICH Q2(R1) guidelines for system suitability, linearity, accuracy, precision, robustness, and specificity. The method showed good linearity in the concentration range of [e.g., 10–100 µg/mL] with correlation coefficient (R²) > 0.999. The developed method was successfully applied for the estimation of galantamine in marketed tablet formulations