The Anti-Inflammatory Effects of Solanum Surattense Fruit: A Combined Network Pharmacology and Experimental Study

Medicinal plants are special because they can make many different chemicals that have strong effects on the body. A lot of research has been done on these plants, and many useful chemicals with great healing abilities have been found. Traditional medicine often uses a plant called Solanum surattense, which grows in the wild. Different parts of this plant like roots, stems, leaves, fruits, and seeds have chemicals that help the body in many ways. These chemicals have been studied a lot, and they have been shown to protect the liver, heart, and lungs, and even help keep away mosquitoes. After careful study, four special chemicals were found in the plant: diosgenin, campesterol, solasonoine, and solamargine. When these chemicals were tested against standard treatments, they showed strong healing power. Recent studies support the idea that Solanum surattense has real medicinal value. When the body responds to something that might be harmful, it can cause inflammation. Antioxidants stop the process that leads to free radicals. It is important to find anti-inflammatory chemicals that are safe for the future because long-term use of steroids as anti-inflammatory drugs can be dangerous. This study looked at the anti-inflammatory and antioxidant properties of Solanum surattense seeds and leaves in a lab setting. Maceration was used to make the ethanolic extract from the seeds and leaves of Solanum surattense. The percentage inhibition of albumin denaturation, membrane stabilisation, and protease inhibition were used to check the anti-inflammatory effects of the extracts from the seeds (SE) and leaves (LE). The antioxidant activity was tested using the DPPH free radical scavenging assay, which uses 1,1-diphenyl-2-picrylhydrazine. The seeds were extracted using ethanol, ethyl acetate, acetone, and water. The ethanolic extracts from the seeds and leaves of Solanum xanthocarpum showed both anti-inflammatory and antioxidant properties. The acetone extract had stronger anti-inflammatory effects compared to the ethyl acetate and aqueous extracts. The findings show that Solanum surattense has both anti-inflammatory and antioxidant abilities.