A Hospital Based Prospective Interventional Study to Measure Medication Efficacy in Gastroesophageal Reflux Disease

Gastroesophageal reflux disease is a prevalent global condition associated with increasing prevalence rates. Effective management involves lifestyle modifications and pharmacological interventions. However, challenges such as non- adherence to treatment and irrational drug use persist, impacting clinical outcomes and healthcare costs. This study primarily aimed to measure medication efficacy in GERD. A total of 182 GERD patients participated. Participants were categorized into intervention and control groups for evaluating medication efficacy, lifestyle factors and, adherence which was observed in pre and post analysis. The intervention group showed significant improvements in dietary habits, sleep quality, and physical activity, correlating strongly with reduced GERD symptoms based on substantial decreases in FSSG scores. PPIs were the predominant treatment, effectively controlling symptoms, while three and four-drug combinations demonstrated higher rates of esophageal healing compared to two-drug regimens. Symptom improvement was notable, with FSSG scores decreasing significantly from 27.47 to 16.98 (p=0.0001), and patients with erosive esophagitis showing improved esophageal healing. Post-intervention, adherence rates improved from 38.96% to 45.60%, with rational medication use observed in dosage and timing, ensuring optimal therapeutic outcomes. This study concludes that targeted lifestyle modifications significantly reduce GERD symptoms. PPIs remain highly effective for symptom control, and combination therapies offer superior esophageal healing. Improved adherence to treatment, facilitated by patient education and reminder systems, enhances therapeutic outcomes. The rational use of medications, with correct dosages and timing, contributes to optimal patient care. Overall, the findings underscore the importance of comprehensive management strategies, combining lifestyle interventions and pharmacological treatments, in effectively managing GERD.