BIOLOGICALLY INACTIVE GROWTH HORMONE SYNDROME IN CHILDREN: DIAGNOSIS, TREATMENT, AND SOCIAL ADAPTATION (LITERATURE REVIEW)

Biologically inactive growth hormone syndrome (BIGHS) is a rare genetically determined pathology characterized by short stature despite normal or elevated growth hormone levels and decreased insulin-like growth factor-1 (IGF-1) levels. The article presents a literature review on the etiology, pathogenesis, clinical features, diagnosis, and treatment of BIGHS. The importance of early diagnosis using hormonal tests and molecular genetic analysis, which enables timely initiation of recombinant growth hormone therapy and improvement of children's physical and psychoemotional development, is emphasized. The article also considers the peculiarities of the social adaptation of patients with this pathology.