Axonal injury is a targetable driver of glioblastoma progression

Axonal injury is a targetable driver of glioblastoma progression This resource provides the R code to reproduce key results described in Clements, Tang, Baronik, Simpson Ragdale et al. "Axonal injury is a targetable driver of glioblastoma progression". Contents: R codes for reproducing Fig2 and FigS2; Raw H&E images for 10X visium ST data (RAW H&E.zip). A quick demo For example, executing `~/Axonal-Injury/R_Figure2/Fig_2b.R` will reproduce Figure 2b from the paper. Expected output and runtime The output are reproduced figures from main figure 2 and supplementary figure 2. Expected runtime is less than 15 minutes for each figure. Getting started 1. Load all R code/RData from ./utils;2. ./RData contains RData files needed for reproducing corresponding figures from the paper;3. ./R_Figure2 contains code for reproducing main figure 2;4. ./R_SUPFIG2 contains code for reproducing supplementary figure 2;5. Please modify the path in the R code where there is needed. Approximate installation time of the above R packages The installation time of the above R packages may take around 3-5 hours.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-06-06
DOI
https://doi.org/10.5281/zenodo.15608353
Citations
1
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.63
Controls
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article

Axonal injury is a targetable driver of glioblastoma progression

1 citations
Zenodo (CERN European Organization for Nuclear Research)
Glioma Diagnosis and Treatment
1.63
article

Axonal injury is a targetable driver of glioblastoma progression

article en
1 citations

Abstract

Axonal injury is a targetable driver of glioblastoma progression This resource provides the R code to reproduce key results described in Clements, Tang, Baronik, Simpson Ragdale et al. "Axonal injury is a targetable driver of glioblastoma progression". Contents: R codes for reproducing Fig2 and FigS2; Raw H&E images for 10X visium ST data (RAW H&E.zip). A quick demo For example, executing `~/Axonal-Injury/R_Figure2/Fig_2b.R` will reproduce Figure 2b from the paper. Expected output and runtime The output are reproduced figures from main figure 2 and supplementary figure 2. Expected runtime is less than 15 minutes for each figure. Getting started 1. Load all R code/RData from ./utils;2. ./RData contains RData files needed for reproducing corresponding figures from the paper;3. ./R_Figure2 contains code for reproducing main figure 2;4. ./R_SUPFIG2 contains code for reproducing supplementary figure 2;5. Please modify the path in the R code where there is needed. Approximate installation time of the above R packages The installation time of the above R packages may take around 3-5 hours.

Zenodo (CERN European Organization for Nuclear Research)
University of California, San Francisco (US), Manchester Academic Health Science Centre (GB), Cancer Institute (WIA) (IN), London Cancer (GB), MRC Laboratory for Molecular Cell Biology (GB), CRUK Lung Cancer Centre of Excellence (GB), University College London (GB), Imperial College London (GB), Kindai University (JP)
Openalex Percentile: Top 11%
Glioma Diagnosis and Treatment
1.63
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Axonal injury is a targetable driver of glioblastoma progression · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS