Gillian Barre Syndrome: A Comprehensive Review

Gillian–Barre syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. Guillain-Barre syndrome (GBS) is now considered a heterogeneous group of related disorders, that includes Miller Fisher syndrome and various GBS subtypes [4]. Guillain-Barré Syndrome (GBS) is an umbrella term that describes several clinically and electro physiologically heterogeneous disorders that share the common feature of acute onset regional or generalized flaccid paralysis with or without sensory loss [1]. Immune-mediated immune responses may play a role in the development of GBS by interacting with brain tissue. Because the infected organism contains homologous epitopes, it initiates molecular and cell immune responses that interact with the ganglioside surface areas of the peripheral nerve (cell imitation) [5]. The severity of Guillain-Barré syndrome is exacerbated by these variables, especially in low-income and middle-income countries where healthcare systems are already constrained and struggle to meet the demands of other diseases [6].