Assessment of Trimester Base Immunoglobulin M (IgM) Variation Amongst Pregnant Women Attending Antenatal Clinic in A Tertiary Health Facility

In view of complex immunological adaptations associated with the preservation of pregnancies up to term; immunoglobulin M (IgM) was assessed in subjects including control group of 20 non-pregnant and test group of 60 pregnant women in whom serum IgM levels for 1st, 2nd and 3rd trimesters was measured by chemiluminescent immunoassay (CLIA), using MAGLUMINO IgM test kit protocols. The results showed gradual decreasing order of mean serum IgM levels from the first (580.60 ± 70.91), second (495.87 ± 51.44) and third (455.81 ± 44.66) trimesters, in comparison to control (619.26 ± 65.10). However, this variation was not statistically significant (p<0.05); suggestive of an inverse relationship between trimester of pregnancy and IgM level that may require further investigations to provide more insight.