A Review Article Impurity Scavengers Roadmap for Platinum Derivative Formulations

Platinum derivative formulations have been facing serious impurity issues, which can lead to degradation of the drug product, affecting its safety and efficacy. The current review article aims to highlight the mitigation of impurities in platinum derivative formulations by focusing on product design and development, as well as the regulatory perspective. The factors contributing to impurity issues in platinum derivative formulations include environmental factors, chemical reactivity, thermodynamic instability, ligand exchange, excipient impurities and contaminants, and container closure system. This review article will provide an overview of the key challenges and solutions for mitigating impurities in platinum derivative formulations.