A Review: Antiulcer Buccal Film of Guava Leaf Extract

Guava (Psidium guajava) leaf extract has gained significant attention due to its antiulcer properties attributed to its rich content of flavonoids, tannins, and antioxidants. The development of buccal films as a drug delivery system offers a convenient, effective, and non-invasive means of delivering therapeutic agents. This review examines the formulation and evaluation of antiulcer buccal films incorporating guava leaf extract and explores the potential of natural polymers in enhancing film characteristics and drug release. It passes the first pass metabolism and shows action fast. The present study focuses on the development and evaluation of an antiulcer buccal film formulated using guava leaf extract (Psidium guajava), known for its potent antimicrobial, antioxidant, and anti-inflammatory properties. The guava leaf extract was prepared and incorporated into a bio adhesive buccal film matrix using polymers like hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA). The films were evaluated for physicochemical properties, including thickness, tensile strength, folding endurance, and drug content uniformity. In vitro release studies demonstrated sustained release of active constituents, ensuring prolonged therapeutic action. The antiulcer activity was assessed using an experimental ulcer model, where the films exhibited significant ulcer healing effects, likely due to the phytochemicals such as flavonoids and tannins present in guava leaves. The developed buccal films offer a promising, patient-friendly approach to managing ulcers, improving drug bioavailability, and minimizing side effects compared to conventional oral therapies.[7] [13-17].