Association of ACE2 Gene Polymorphisms (rs2285666 and rs4646142) with Dyslipidemia in Iraqi Patients with Type 2 Diabetes Mellitus A Sex-Stratified Analysis

Abstract: Background: Growing evidence suggests the involvement of angiotensin-converting enzyme 2 (ACE2) in lipid metabolism and cardiovascular homeostasis. Genetic variations in ACE2 have been linked to metabolic disorders, including dyslipidemia, which is a hallmark of type 2 diabetes mellitus (T2DM). However, the association of ACE2 polymorphisms and dyslipidemia in T2DM patients, particularly in Iraqi populations, remains underexplored. Aim: This study aimed to investigate the association of ACE2 gene polymorphisms (rs2285666 and rs4646142) with dyslipidemia in Iraqi patients with T2DM, stratified by sex. Methods: A case-control study was conducted involving 463 T2DM patients (222 women and 241 men). Based on serum lipid profiles, participants were stratified into dyslipidemic (cases) and non-dyslipidemic (control) groups. Genotyping of ACE2 polymorphisms was performed using PCR-based methods, and serum ACE2 levels were quantified using ELISA. Results: The AA genotype of rs2285666 SNP was significantly associated with dyslipidemia in women (OR = 3.19, 95% CI = 1.31–7.78, p = 0.01), while the A allele was associated with dyslipidemia in men (OR = 2.36, 95% CI = 1.27–4.39, p = 0.006). High ACE2 levels, elevated atherogenic indices, and adverse lipid profiles were observed in carriers of the A allele. No significant association was found for rs4646142 SNP. Conclusion: The rs2285666 SNP was associated with dyslipidemia in Iraqi T2DM patients, with sex-specific differences in risk. The ACE2 variants may contribute to dyslipidemia pathogenesis in T2DM and highlight the potential for personalized risk stratification and therapeutic targets. Keywords: ACE2, rs2285666, rs4646142, Dyslipidemia, T2DM, Association. Title: Association of ACE2 Gene Polymorphisms (rs2285666 and rs4646142) with Dyslipidemia in Iraqi Patients with Type 2 Diabetes Mellitus A Sex-Stratified Analysis Author: Ali B. Abulrazzaq, Ibrahim Rahem Jassim Al-Aadily, Maha Radhi Abass, Majid Kadhum Hussain International Journal of Life Sciences Research ISSN 2348-313X (Print), ISSN 2348-3148 (online) Vol. 13, Issue 2, April 2025 - June 2025 Page No: 1-10 Research Publish Journals Website: www.researchpublish.com Published Date: 04-April-2025 DOI: https://doi.org/10.5281/zenodo.15149459 Paper Download link (Source) https://www.researchpublish.com/papers/association-of-ace2-gene-polymorphisms-rs2285666-and-rs4646142-with-dyslipidemia-in-iraqi-patients-with-type-2-diabetes-mellitus-a-sex-stratified-analysis