A scoping review of mesenchymal stem cell metabolites: Implications for oral wound healing

Mesenchymal stem cell (MSC) metabolites show considerable promise in enhancing oral wound healing due to their regenerative properties, including anti-inflammatory, collagen-promoting, and angiogenesis-stimulating effects. This scoping review consolidates current research on MSC metabolites, focusing on their roles in accelerating wound closure, reducing infection risk, and improving tissue integrity within the unique environment of the oral cavity. The findings reveal that while MSC metabolites offer a novel therapeutic approach with significant potential benefits, challenges such as variations in metabolite and quality need to be addressed to ensure consistent clinical outcomes. This review highlights the need for further studies to refine MSC metabolite applications, aiming to improve wound healing treatment efficacy in dentistry and oral health care.