A Comparative Formulation Study of Furosemide Oral Film

Centrifugal electrospinning is an advanced technique for the development of nanofibers. It is a vital part of a novel drug delivery system. Oral films are the most convenient dosage form for administration. Hence, oral film is selected as the final dosage form. The study involved the preparation of polymeric solutions such as polyvinyl alcohol and polyvinyl pyrrolidone, and the use of a Design of Experiment for getting trial batches. Furosemide-loaded oral films are prepared by two methods, namely, solvent casting and the centrifugal electrospinning method. The optimized formulation via solvent casting was further utilized for the fabrication of nanofiber oral film using a central electrospinning method. Both oral films were comparatively evaluated by analytical and performance characterization tests, including DSC, FTIR, XRD, in vitro dissolution studies, and disintegration time. The developed nanofiber oral film significantly enhances the solubility of Furosemide, indicating its potential as an effective platform for improving dissolution rate and bioavailability.