Design, Development and Characterization of Transdermal Patches by Using Different Polymer

With a biological half-life of two hours and antifungal action, clotrimazole has numerous gastrointestinal adverse effects when taken orally. Three polymers—Eudragit RS-100, Hydroxymethyl Propyl Cellulose (HPMC), and Ethyl Cellulose (EC)—were used in the solvent casting procedure to create the transdermal patch with clotrimazole in order to overcome these negative effects. Propylene glycol was used as a plasticizer and penetration enhancer, and methanol and dichloromethane were used as solvents at the same concentration. The FTIR spectrophotometer was used to analyse the compatibility study for each produced patch. The produced patches were assessed for their drug concentration, thickness, folding endurance, weight change, moisture content, and in-vitro permeation testing. Further prepared patches characterized for scanning electron microscopy. According to the results, the combination of three polymers exhibits favourable physical characteristics, and formulation F3 exhibits more drug release than formulations with two polymers.