An Impact of Liver Cirrhosis on Haematological, Renal & Hepatic Parameters

Abstract: Background: Liver disease is a significant global health issue leading to liver failure, cirrhosis, and cancer. Alcohol is a major cause, accounting for 5% of deaths in India. Understanding liver disease molecular mechanisms is vital for developing new treatments and reducing cirrhosis-related mortality. Objective of The Study: To Assess & Compare the haematological, renal, and liver function parameters among cases and controls. Material and Methods: The study was conducted at Index Medical College hospitals in Indore. This study included individuals with chronic alcoholic liver disease who sought medical attention at Gastroenterology departments of Medical College hospitals located in Indore and estimate the Haematological Investigation, Kidney Function Test & Liver Function Test. Result: The study findings demonstrated Haemoglobin concentration and platelet count are highly statistically significant, Urea are statistically significant while Creatinine is a highly statistically significant in a Liver Cirrhosis Cases, and Total Bilirubin, AST, ALT and Albumin are highly statistically significant, while Direct Bilirubin & ALP are statistically significant. Total Protein is statistically not significant in a Liver Cirrhosis Cases. Conclusion: Liver Cirrhosis shows Hematologic Abnormalities and Public Health Issues. Study evaluates mechanisms regulating hemostasis, coagulation, and fibrinolysis. Anemia in cirrhosis linked to hemorrhage, iron deficiency, and nutrition.