DIAGNOSTIC ROLE OF CYTOKINE PROFILE IN CHRONIC PYELONEPHRITIS IN CHILDREN.

Currently, pyelonephritis, as a nonspecific microbial-inflammatory disease of the renal calyceal-pelvic system and tubulointerstitial kidney tissue, has a high prevalence among the pediatric population. Primarily, pyelonephritis, although less common than lower urinary tract infections, poses a serious threat to children's health and, in severe cases, can lead to kidney damage and the development of chronic kidney disease [3,6]. The high prevalence of severe complications of pyelonephritis, such as nephrosclerosis, kidney failure, and renal arterial hypertension, justifies the need for timely early diagnosis and prevention of this disease in children and adolescents. The outcome of chronic pyelonephritis (CP) depends on early diagnosis and timely initiation of therapy [2,5].