Formulation Strategies and Evaluation Techniques for Salicylic Acid-Based Moisturizing Creams: A Comprehensive Review

A popular well-known beta-hydroxy acid with keratolytic, comedolytic, and anti-inflammatory qualities is salicylic acid also helps in exfoliation process, making it a significant active component in dermatological products that treat psoriasis, acne, and other hyperkeratotic skin disorders. However, because of its low solubility, sensitivity to pH, and propensity for skin irritation, including it into moisturizing cream compositions presents special hurdles. This article offers a thorough summary of the formulation techniques used to maximize the stability, effectiveness, and skin compatibility of moisturizing creams containing salicylic acid. It talks about choosing the right emulsifiers, emollients, penetration enhancers, and pH modifiers to support the finished product's functional and cosmetic qualities. The evaluation methods utilized to evaluate physicochemical characteristics, medication release, skin hydration, irritation potential, and overall product performance are also examined in the review. This work attempts to assist researchers and formulators in creating salicylic acid-based moisturizing creams that are both effective and consumer-friendly by critically examining current formulation processes and testing methodologies.