UV-vis Spectrophotometric Method for Estimation of Voriconazole in Tablet

A simple, specific and sensitive UV-vis spectrophotometric method has been developed using buffer pH 1.2 as solvent for the estimation of voriconazole in tablet. The drug shows maximum absorbance at 256 nm. The technique demonstrated a linear response within a concentration range of 10-50 μg/ml, achieving a correlation coefficient of 0.9999. The precision study shows the % RSD was 0.566. Recovery studies showed accuracy of 101%. The LOD and LOQ found to be 1.57 µg/mL and 4.77 µg/mL respectively. The validation parameter outcomes showed that the method demonstrated accuracy, precision, reproducibility, sensitivity. Therefore, this technique is beneficial for regular quality control assessments for determining voriconazole in solid dosage forms.