GENETIC STRUCTURE OF ACUTE MYELOID LEUKEMIA

Acute myeloid leukemia (AML) - is the most common acute leukemia among adults. The pathophysiology of the disease is associated with cytogenetic abnormalities, gene mutations and aberrant gene expression. Molecular genetic features of AML underlie the stratification of patients into risk groups and determination of treatment tactics. Chromosomal aberrations such as t(6;9)(p23;q34.1), DEK:NUP214, translocations involving the KMT2A gene (MLL), mutations in the RUNX1, TP53, ASXL1 genes are factors of unfavorable prognosis.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-05-01
DOI
https://doi.org/10.5281/zenodo.15384526
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
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article

GENETIC STRUCTURE OF ACUTE MYELOID LEUKEMIA

Zenodo (CERN European Organization for Nuclear Research)
Acute Myeloid Leukemia Research
article

GENETIC STRUCTURE OF ACUTE MYELOID LEUKEMIA

article en

Abstract

Acute myeloid leukemia (AML) - is the most common acute leukemia among adults. The pathophysiology of the disease is associated with cytogenetic abnormalities, gene mutations and aberrant gene expression. Molecular genetic features of AML underlie the stratification of patients into risk groups and determination of treatment tactics. Chromosomal aberrations such as t(6;9)(p23;q34.1), DEK:NUP214, translocations involving the KMT2A gene (MLL), mutations in the RUNX1, TP53, ASXL1 genes are factors of unfavorable prognosis.

Zenodo (CERN European Organization for Nuclear Research)
Bukhara State Medical Institute named after Abu Ali ibn Sino (UZ)
Good health and well-being
Openalex Percentile: Top 38%
Acute Myeloid Leukemia Research
DOIOpen Access PDFOpenAlex
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GENETIC STRUCTURE OF ACUTE MYELOID LEUKEMIA · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS