EFFECTS OF Bryophyllum Pinnatum EXTRACTS ON LIVER ENZYME FUNCTION IN MALE WISTAR ALBINO RATS EXPOSED TO KEROSENE

This study examined the hepatoprotective effects of Bryophyllum pinnatum extracts on the liver enzyme function of male wistar albino rats exposed to kerosene. The rats were divided into five (5) groups: blank control, negative control, low-dose extract, medium-dose extract, and high-dose extract. All groups were exposed to kerosene inhalation (except the blank control group, and the experiment lasted for 28 days. Then, liver enzyme activities (ALT, AST, ALP, and GGT) were measured, and the results showed a significant increase in liver enzyme activities, indicating hepatotoxicity. Treatment with Bryophyllum pinnatum extract significantly reduced liver enzyme activity, suggesting hepatoprotection. Results showed a dose-dependent reduction in AST enzyme activities, with the highest dose (28.85 ± 0.12) exhibiting the most significant reduction (p<0.05) followed by the medium-dose at (30.74 ± 0.32) when compared with the blank control (30.48 ± 0.01)) at week 2. The results followed the same pattern at week 4. These findings indicate that Bryophyllum Pinnatum extracts have the ability to mitigate kerosene-induced hepatotoxicity, supporting its potential use as a therapeutic agent