Design And Evaluation of Anti-Folliculitis Cream Loaded with Silver Nanoparticle of Boerhavia Diffusa (L.)

This study focused on developing and evaluating an anti-folliculitis cream loaded with silver nanoparticles (AgNPs) synthesized from Boerhavia diffusa (L.), a plant with known antimicrobial properties. The plant was collected from Ayankalam, Malappuram, and authenticated at Calicut University. Bioactive compounds were extracted using ethanol and water via maceration, revealing alkaloids, flavonoids, tannins, and saponins. AgNPs were synthesized using the plant extract, and their characteristics were analyzed using UV-Visible spectrometry, HR-TEM, FE-SEM, EDAX, XRD, FTIR, and Zeta potential analysis. These techniques confirmed the size, shape, and composition of the nanoparticles. Both the plant extract and synthesized AgNPs demonstrated strong antimicrobial activity and wound-healing properties. The topical cream formulated with the AgNPs was evaluated for its physical appearance, spreadability, pH, and drug release efficiency, all of which were found to be favorable for topical use. The study underscores Boerhavia diffusa's potential as a source for bioactive compounds and highlights the efficacy of AgNPs synthesized from the plant in antimicrobial and wound-healing applications. This research offers promising prospects for developing novel nanomedicines using natural plant extracts.