Evaluation of Oral Strips for Enhanced Water-Soluble Vitamin Delivery for Vitamin B12

Vitamin B12 is a water-soluble vitamin found in some foods and is available as a dietary supplement and prescription medication. It contains cobalt, making it a part of the cobalamins. Methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12. Other forms, hydroxycobalamin and cyanocobalamin, become biologically active when converted to methylcobalamin or 5-deoxyadenosylcobalamin. The study aims to design and evaluate oral strips for improved Vitamin B12 delivery using various polymers and technologies. It will focus on developing physicochemical properties, mucoadhesive strength, and in-vitro release. The study will also investigate the impact of formulation parameters on Vitamin B12 delivery, optimize formulation and process parameters, compare the performance of developed oral strips with conventional systems, explore the potential of oral strips for digital health technologies, and contribute to the development of effective oral delivery systems for vitamins and nutrients. Oral disintegration films loaded with Vitamin B12 were formulated successfully by solvent-casting method. Formulated OFs were homogenous and transparent with a neutral surface pH. ODFs containing high amount of super disintegrant and low amount of polymer, i.e., formulation F6 had shown optimum disintegration and in vitro release, when compared with other formulations. From the results, it can be concluded that formulated OFs release the drug into systemic circulation rapidly from the site of administration providing an alternative approach to facilitate Vitamin B12 requirment in the body.