ENDOCRINE DISRUPTION AND NEUROCARCINOGENESIS – ENDOCRINE DISRUPTING CHEMICALS, METASTASIS, AND THE BLOOD-BRAIN BARRIER

Endocrine Disrupting Chemicals (EDCs) represent a significant public health threat due to their ability to disrupt hormonal homeostasis, compromise the blood-brain barrier (BBB), and promote neurocarcinogenesis and metastasis. This review synthesizes current evidence on the multifaceted mechanisms by which EDCs, such as bisphenol A and phthalates, induce oxidative stress, inflammation, and hormonal dysregulation, fostering environments conducive to brain tumor development and spread. We explore how EDCs interfere with critical processes like epithelial-mesenchymal transition (EMT) and BBB integrity, enabling neurotoxic agents and carcinogens to infiltrate the brain. Transgenerational studies further highlight the long-term risks of EDC exposure, linking parental exposure to elevated brain tumor incidence in offspring. By integrating recent research and case studies, this review underscores the urgent need for stringent regulations, targeted public health interventions, and interdisciplinary research to address gaps in understanding low-dose exposure effects and molecular pathways. Ultimately, mitigating EDC-driven neurocarcinogenesis requires a holistic approach combining policy action, scientific innovation, and public awareness to safeguard neurological health globally.