Innovative wound therapy: The role of herbal nano formulations

Wound healing is a complex process, and the management of wounds is a challenge. Herbal remedies have now become essential for the management of wound. Various herbal preparations have been reported to speed up the process of wound healing having anti-microbial activity, antioxidant and anti-inflammatory to improving epithelization, neovascularization, formation of granulation tissue, collagen synthesis, and wound contraction. Many single-herb and multi-plant extract preparations have been reported to accelerate wound healing activity in freshly prepared incisional and excisional experimental wound models. However, skin barrier is not easy to permeate and influenced by many factors like high hydrophobicity, poor stability, poor penetration through skin, poor solubility. These factors can be overcome by formulating in to nanotechnology- based drug delivery system to increase their efficacy in wound healing. Nanomedicine has revolutionized the field of pharmacotherapeutics in recent decades, enabling innovative approaches in the field of medicine. Here, we reviewed plant based Nano carriers for wound treatment; the present review examines the available research into the use of Nano carriers in the wound healing of herbal remedies. It identifies the various Nano formulation approaches that have been developed and successfully used as a means to enhance the potential for wound of natural bioactive, including Nano emulsions, liposomes, phytosomes, microspheres, transferosomes, nanoparticles, nanoemulgels, and nanofibers.