Review on Naso-Pulmonary Drug Delivery System

Nasal drug delivery has received a great deal of attention as a Convenient, reliable and promising method for the systemic Administration of drugs. This is due to high vascularity, large surface Area, the avoidance of hepatic first pass metabolism, gut wall Metabolism and/or destruction in gastrointestinal. the application of nasopulmonary drug delivery systems a little bit challenging. Studying the parameters of nano- or microparticles (such as particle shape, size, stealth ability from the immune clearance mechanisms, etc.) that enable them to reach the desired site of action via the nasopulmonary route is very crucial and provides important information, which should be taken into account while preparing a nasopulmonary drug delivery system .Nasopulmonary delivery system (NPDS) has produced a significant interest as a simple, reliable, and promising approach for the systemic administration of pharmaceuticals. The intranasal route can improve patient convenience, comfort, and compliance because it is basically painless and simple for the physician or patient to use. It is also described how nasopulmonary medication delivery devices might be used to treat a variety of Illnesses, including allergies, respiratory issues, and systemic problems. In order to maximize the Effectiveness and safety of nasopulmonary drug delivery systems. Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to Deliver the drugs to the treat most crisis CNS diseases (i.e. Parkinson’s disease, Alzheimer’s disease) because it Requires rapid and/or specific targeting of drugs to the brain.