The role of non-invasive brain stimulation (NIBS) in post-stroke motor recovery: synergies with antihypertensive therapy

Stroke is one of the leading causes of motor disability worldwide, further emphasizing the need for novel strategies in rehabilitation. In this research, the authors investigate the role of non-invasive brain stimulation (NIBS) in the recovery of motor function following stroke and coordination with antihypertensive therapy in an integrated system. The present study will be a randomized clinical trial in the selected hospitals of Uzbekistan and will examine the additive effect of NIBS techniques (i.e., TMS and tDCS) and antihypertensive treatment on improving motor function, neuroplasticity, and blood pressure control. The major hypothesis is that using both these two strategies in combination will markedly increase the effectiveness of rehabilitation through increasing the neuronal mechanisms and cerebral blood flow. This research will use clinical assessment, electrophysiological observation, and neuroimaging to gather the data and analyze it with the help of sophisticated statistical analysis. The results of this study should provide a complete system of individualized post-stroke rehabilitation protocols in different groups, especially the Central Asian population.