Comprehensive Review of Breast Cancer Cell Lines: A Guide to Selecting the Optimal Cell Line for Targeted Research

Around 1.5 million women are diagnosed with breast cancer disease every year, being a major reason women have the highest death rates from cancer. Research in breast cancer is ongoing while the breast cancer cell lines play an important role in molecular diagnostics of the breast cancer, selecting the proper cell line for targeted research is critical. This review introduces classification of breast cancer cell lines, clears some ambiguous information on (MDA-MB- 231, MCF-7, T-47-D, MDA-MB-453, MDA-MB-468 and ZR-75-1) breast cancer cell lines, molecular features, morphological characteristics, functional three-dimensional studies that increase understanding of breast cancer cell lines and help researchers make the proper choice and broaden the selection of cell lines for relevant studies. Lastly, we propose some future directions for studies aimed at breast cancer animal models.