Doxycycline Induced Hypoglycemia - A Case Report

A 59-year-old female with a history of chronic obstructive pulmonary disease (COPD) on home BiPAP presented with shortness of breath (SOB) for 2 days. The patient was started on Piperacillin + Tazobactam 4.5 gm IV TDS and Inj. Doxycycline 100 mg IV BD for suspected bacterial infection. During the course of antibiotic therapy, the patient developed hypoglycemic seizures. She was intubated and transferred to the Medical Intensive Care Unit (MICU), where recurrent hypoglycemic episodes were managed. After six days of treatment, Doxycycline was discontinued, leading to the resolution of the hypoglycemia. This case underscores the importance of recognizing the potential for Doxycycline-induced hypoglycemia, particularly in patients with preexisting medical conditions.