MORPHOLOGICAL ALTERATION OF THE SPLEEN IN EXPERIMENTAL RHEUMATOID ARTHRITIS AFTER PATHOGENIC TREATMENT

pomegranate extract has an anti-inflammatory effect in experimental arthritis. Pomegranate juice has anti-inflammatory and chondroprotective effects. The result of systematic reviews showed that studies of humans, animals and in vitro showed the positive effects of pomegranate on clinical signs, inflammatory and oxidative factors of rheumatoid arthritis. Pomegranate is able to overcome its complications by reducing inflammation and oxidative stress. Punicalagin, an active substance derived from pomegranate peels, in the mouse model of collagen-inducing arthritis, is an inhibitor of joint inflammation, damage to the tissue of the spine and destruction of systemic bones. Punicalagin may be one of the natural therapeutic compounds that can relieve the development of rheumatoid arthritis by modulating the NF - aB pathways by suppressing inflammation and migration of fibroblast-like synoviocytes. Punicalin has had beneficial effects on IL-1 β - and TNF - α-stimulated chondrocytes and lower metabolic disorders [4,5,6].