Invasomes: Potential Nanocarrier System for Transdermal Delivery of Drug Molecule

Transdermal drug delivery refers to the drug administration route through the skin that achieves the local or systemic treatment approved for clinical use. Invasomes are novel vesicular systems that exhibit improved transdermal penetration compared to conventional liposomes. These vesicles contain phospholipids, ethanol, and terpene in their structures; these components confer suitable transdermal penetration properties to the soft vesicles. Ethanol, terpenes and phospholipids are the key structural composition, systematize physicochemical properties of invasomes. Nanovesicles can enhance the skin's permeability, which means they allow larger or less penetrative drugs to reach deeper layers of the skin. nanovesicles reduce the drug’s absorption into the bloodstream, helping to keep its effects localized. These vesicular systems, deliver the drugs at predetermined rate by controlling and sustaining release as per the requirement. Furthermore, invaomes used in the treatment of eczema, hypertension, acne, cancer, eosinophilic pustular folliculitis, erectile dysfunction, fungal infections, photodynamic therapy have also been discussed.